Another great basic research done on an inverted SPIM microscope platform.
Prof Jan Ellenberg has published another article on Biorxiv. This article shows two separate bipolar spindles form in the zygote at the beginning of mammalian life, that independently congress and segregate the maternal and paternal genomes. Prof Ellenberg utilises the high spatio-temporal resolution of light-sheet microscopy to investigate zygotic spindle assembly and joining of the parental genomes. Inverted light-sheet microscope allows fast and high-resolution 3D time-lapse imaging of early embryonic development due to its low phototoxicity and rapid image acquisition.